Med-WINE-Quality Grape-Wine Quality and Mediterranean Diet

Group members: 
Mª José Motilva Casado: 
Research Scientist, CSIC (Responsible for Polyphenols)
Mar Vilanova de la Torre: 
Distinguished Researcher, CSIC (Responsible for Volatiles area)
Silvia Yuste: 
Postdoctoral researcher
Bianca Souza: 
Juana I. Mosse: 
Visiting researcher (CONICET-Universidad de Buenos Aires, Argentina)
Collaborator researchers: 
Carmen-Patricia Pérez Matute: 
CIBIR (Centro de Investigación Biomédica de La Rioja, Fundación Rioja Salud)
María Iñiguez Martínez: 
CIBIR (Centro de Investigación Biomédica de La Rioja, Fundación Rioja Salud)
Belinda Matute: 
Fundación Rioja Salud, Servicio de Neurología, Hospital San Pedro, Logroño
Sara López Alava: 
Fundación Rioja Salud, Servicio de Neurología, Hospital San Pedro, Logroño
Maria Eugenia Marzo: 
Fundación Rioja Salud, Servicio de Neurología, Hospital San Pedro, Logroño
Federico Castillo: 
Fundación Rioja Salud, Servicio de Neurología, Hospital San Pedro, Logroño
Jose Luis Peñalvo: 
Institute of Tropical Medicine, Antwerp (Bélgica)
Javier Cancela: 
Universidad de Santiago de Compostela, USC
Jesús Yuste: 
Instituto Tecnológico Agrario de Castilla y León, Itacyl
David Uriarte: 
Centro de Investigaciones Científico-Tecnológicas de Extremadura, Cicytex
Esperanza Valdés: 
Centro de Investigaciones Científico-Tecnológicas de Extremadura, Cicytex
Amelia Montoro: 
Instituto Técnico Agronómico Provincial de Albacete, ITAP-Fundescam
Luca Rolle: 
Universidad de Turín (Italia)
Susana Rio-Segade: 
Universidad de Turín (Italia)
José Maria Oliveira: 
Universidade do Minho (Portugal)
Wasley Duarte: 
Universidad de Lavras (Brasil)
Research goals:

The group has a clear multidisciplinary character, and its main activity is the grape and wine research, from physicochemical (phenolic and volatile fractions) and sensory properties to the importance of wine in the Mediterranean diet. The specific aims are grouped in different research lines, as detailed below:

Activity 1. Study of the minority fractions, responsible for grape and wine quality. This activity includes different sub-activities:

  • 1.1. Analysis of the aromatic quality of grapes and wine, by gas chromatography coupled to mass spectrometry (GC-MS).
  • 1.2. Analysis of grape and wine phenolic fraction using advanced liquid chromatography techniques: targeted metabolomics (UHPLC-QqQ-MS/MS) and untargeted metabolomics (SYNAPT XS ACQUITY UPLC system).
  • 1.3. Grape response to biotic and abiotic stresses. Improve the grape and wine quality by a controlled stress in the plant and post-harvest, stimulating glycosylated forms and phenolic compounds. Study of volatile compounds in plant-plant communication as defense responses against stress.
  • 1.4. Application of digital tools to estimate the grape quality. Use of Visible-NIR hyperspectral cameras to ripening control in basis to correlations between images and quality parameters.
  • 1.5. Sensory characterization of grapes, wines and distillates. Correlations between chemical composition and sensory descriptors. To develop new methods of sensory analysis of grapes and other fruits.

This activity line is open to any vegetable product such as virgin olive oil, fruit, cereals and hops, and others, as well as by-products from the food industry.

Activity 2. Valorization of by-products from the winemaking process to obtain new ingredients with high content of bioactive compounds, with special interest in polyphenols, and their application in the formulation of new foods as well as crop protection.

Activity 3. Advance in the study of the mechanisms of the healthy properties of wine polyphenols, through moderate consumption in the context of the Mediterranean Diet. Identification of biomarkers of wine consumption as well as wine consumption in the diet, through the application of target and untargeted metabolomics techniques.

Active Research Projects

Project title: "Relationship between wine consumption, diet and microbiome modulation in Alzheimers Disease in a cohort from La Rioja”

Financing entity:  Ministerio de Ciencia e Innovación. PID2019-108851RB-C22

Participants (Coordinated project):  CIAL-CSIC, Madrid; Instituto de Ciencias de la Vid y del Vino-ICVV, CIBIR-Fundación Rioja Salud.

Duration:  2020-2024

Global objective:  The subproject aims to precise the connections between diet, and wine in particular, and protection against Alzheimers disease (AD) in an environment of other multiple lifestyle factors. A first specific objective is focused on the development of tools for characterizing lifestyle factors potentially associated with AD, in particular an app mobile application prototype for the self-report of diet and lifestyle habits, and especially for wine consumption, in a simple and user friendly manner. In a second objective and as main focus of the subproject, we will study the dietary and lifestyle factors associated with prevalent subclinical Alzheimer's disease in La Rioja cohort, with special attention to the wine consumption, and microbiota and metabolic features. In the third objective, the subproject will be focused on animal-based investigations about the mechanisms of the protective effects against AD of moderate wine consumption in relation to the modulation of intestinal microbiota. For this proposal, an AD-induced mice model will be used to specifically explore the modulation effects of wine/wine polyphenols on gut microbiota through the fecal microbiota transplantation.


Project Title: “Annual water and agronomic management in red grape varieties to improve their productive and qualitative behavior and reduce effects of climate change (WFW-Irrivitis)”

Financing entity:  Ministerio de Ciencia e Innovación, PID2019-105039RR-C44

Participants (Coordinated project):  Cicitex (Extremadura), Fundescam (Castilla-La Mancha), Itacyl (Castilla y León), Universidad de Santiago de Compostela (Galicia), Instituto de Ciencias de la Vid y del Vino (Logroño)

Duration:  2020-2023

Sub-project from Galicia (USC-ICVV):  Effects of the irrigation frequency and the use of slate waste in the production and quality of Vitis vinifera cv. Mencía: aromatic composition.

Global objective:  Galician vineyards have not been traditionally irrigated, although in the last decade it has had an increase in irrigated surface with the aim of addressing the inter-annual irregularity of the productions, seeking a stabilization in quality and production. Another aspect that justifies the implementation of irrigation systems has been climatic alterations, especially the decrease in rainfall during the summer period and its irregularity, together with slight increases in temperatures. Although there are several studies about the irrigation management in Galician vineyards, in red varieties are limited, being necessary to expand knowledge about when, and how much water apply to improve the efficiency in the use of water, without reducing the quality of grapes. Since the majority red variety in Galicia is Mencía, which accounts for more than 90 % of the surface of the Galician red varieties, the study will be carried out on it.